I’m currently using an Intuos Pro M and on an iMac 5K and I was getting a ton of lag when the computer was doing intensive things, like rendering. The touch surface worked perfectly fine, but the pen was unusable.
I was able to fix this by downgrading the Wacom Driver to 6.3.37-2. Make sure you uninstall all the old stuff first and restart your machine. Hopefully this helps if you’ve been experiencing similar issues.
I also hope that future updates don’t bring back the lag issues